OXIDATIVE STRESS CONTRIBUTES TO SEX DIFFERENCES IN BLOOD PRESSURE IN ADULT GROWTH RESTRICTED OFFSPRING
| Autor: | Thomas P Royals, Nicole E.E. Betson, Barbara T. Alexander, Melanie L. Hill, Bettye Sue Hennington, Jane F. Reckelhoff, Norma B. Ojeda, Julio C. Sartori-Valinotti, Danielle T. Williamson |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Offspring Blood Pressure Biology medicine.disease_cause Kidney Antioxidants Article Cyclic N-Oxides Rats Sprague-Dawley Sex Factors Superoxides Pregnancy Internal medicine Internal Medicine medicine Telemetry Animals Glutathione Peroxidase Fetal Growth Retardation Superoxide Dismutase Kidney metabolism Blood Pressure Determination medicine.disease Catalase Rats Oxidative Stress Endocrinology Blood pressure medicine.anatomical_structure Animals Newborn Pathophysiology of hypertension Hypertension Gestation Spin Labels Female Oxidative stress |
| Popis: | Numerous experimental studies suggest that oxidative stress contributes to the pathophysiology of hypertension and, importantly, that oxidative stress plays a more definitive role in mediating hypertension in males than in females. Intrauterine growth restriction induced by reduced uterine perfusion initiated at day 14 of gestation in the rat programs hypertension in adult male growth-restricted offspring; yet, female growth-restricted offspring are normotensive. The mechanisms mediating sex differences in blood pressure in adult growth-restricted offspring are not clear. Thus, this study tested the hypothesis that sex-specific differences in renal oxidative stress contribute to the regulation of blood pressure in adult growth-restricted offspring. A significant increase in blood pressure measured by telemetry in male growth-restricted offspring ( P P P P P |
| Databáze: | OpenAIRE |
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