Avances en la investigación preclínica del dominio C-Terminal de la cadena pesada de la toxina tetánica en enfermedades neurodegenerativas
| Autor: | Isabel Martínez, Irving Parra, Liliana Mendieta, Félix Luna, Victorino Alatriste, Daniel Limon |
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| Rok vydání: | 2020 |
| Předmět: |
Toxin
MPTP Neurodegeneration Methamphetamine Blood–brain barrier medicine.disease medicine.disease_cause Molecular biology Neuroprotection In vitro chemistry.chemical_compound medicine.anatomical_structure chemistry Neurology In vivo medicine General Earth and Planetary Sciences Neurology (clinical) medicine.drug General Environmental Science |
| Zdroj: | Archivos de Neurociencias. 25:61-76 |
| ISSN: | 1028-5938 |
| Popis: | Tetanus toxin is a polypeptide of 1315 aminoacids of 150 kDa, from which a non-toxic fraction of 50 kDa is extracted that has the ability to cross the blood brain barrier through mechanisms that full-length toxin, have developed to throughout its evolution. We refer to axonal retrograde trip and synaptic jumps. Studies indicate that the C-terminal domain of the tetanus toxin heavy chain, in vivo and in vitro, has neuromodulatory, neuroprotective and antiapoptotic properties when confronted with neurotoxic agents such as MPTP, 6-hydroxypamine or methamphetamine. Therefore, there are high expectations about the therapy with HC-TeTx, and its multiple variants, regarding the neuroprotection they provide. With all before said, we propose that HC has the potential to be a drug with multiple applications. Even with this, questions remain to be resolved and more studies are required to show in detail the aforementioned effects. |
| Databáze: | OpenAIRE |
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