Nonpeptide GPIIB/IIIA receptor antagonists. Part 21: C-6 flexibility and amide bond orientation are important factors in determining the affinity of compounds for activated or resting platelet receptors

Autor:	John H. Hutchinson, Melissa S. Egbertson, Nathan C. Ihle, Ben C. Askew, Wasyl Halczenko, Bohumil Bednar, Mark E. Duggan, Robert J. Gould, John S. Wai, Rodney A. Bednar, George D. Hartman, Karen M. Brashear, John D. Prugh, Thorsten E. Fisher, Michael J. Breslin
Rok vydání:	2000
Předmět:	Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Platelet Glycoprotein GPIIb-IIIa Complex Biochemistry Chemical synthesis Amides In vitro chemistry.chemical_compound Structure-Activity Relationship chemistry Drug Discovery Lactam Molecular Medicine Peptide bond Structure–activity relationship Humans Platelet Selectivity Receptor Molecular Biology circulatory and respiratory physiology
Zdroj:	Bioorganicmedicinal chemistry letters. 10(17)
ISSN:	0960-894X
Popis:	Compound affinity for activated and resting GPIIb/IIIa receptors may differ, and comparison of those differences determines selectivity. Structural features that influence selectivity are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44441041c5da843884ee0f431d14c463 https://pubmed.ncbi.nlm.nih.gov/10987423 Zobrazit plný text záznamu Full Text from ScienceDirect