Potency assays for anistreplase: Comparison of the fibrin plate assay and a 96-well plate assay
| Autor: | Patrick J. Gaffney, D.M.V. van Schie, Deborah P. Beebe |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Bioengineering
Applied Microbiology and Biotechnology Fibrin medicine Potency Plate assay 96 well plate Fibrin plate Pharmacology Analysis of Variance Chromatography General Immunology and Microbiology biology Anistreplase Chemistry Fibrinolysis General Medicine Reference Standards Molecular biology Kinetics Clot lysis biology.protein Biotechnology medicine.drug |
| Zdroj: | Biologicals. 20:129-133 |
| ISSN: | 1045-1056 |
| DOI: | 10.1016/s1045-1056(05)80060-0 |
| Popis: | Several production lots of Anistreplase (Eminase) were assayed for potency by either two fibrin plate assays or a clot lysis assay performed in 96-well microtiter plates. The 96-well plate assay yielded comparable data to the fibrin plate assays and had the advantage of greater efficiency with respect to both time and reagents. As a result the newer method appears to be a suitable alternative to the fibrin plate assays for lot release of Anistreplase. |
| Databáze: | OpenAIRE |
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