Short-Term Impact of Hematopoietic Stem Cell Transplantation on Psychiatric Morbidity and Quality of Life in Hematological Malignancies in Adults

Autor: Deeksha Elwadhi, Lalit Kumar, Sudhir K Khandelwal, Atul Sharma
Jazyk: angličtina
Rok vydání: 2020
Předmět:
medicine.medical_specialty
psychiatric morbidity
Procedure calls
medicine.medical_treatment
RC435-571
Comprehensive Psychopathological Rating Scale
Hematopoietic stem cell transplantation
Hematological malignancies
mesh: • Hematopoietic stem cell transplantation is an arduous but life-saving procedure
Quality of life
mesh: • Acute hospitalization is the period of maximum physical and psychological dysfunction
medicine
In patient
Psychiatry
business.industry
mesh: • Overall
it leads to a decrease in symptoms and improvement in quality of life
quality of life key messages: hematopoietic stem cell transplantation is an arduous but life-saving procedureacute hospitalization is the period of maximum physical and psychological dysfunctionoverall
Cancer
medicine.disease
humanities
Clinical Psychology
Psychiatry and Mental health
quality of life
it leads to a decrease in symptoms and improvement in quality of life
Anxiety
Original Article
medicine.symptom
business
Psychosocial
Zdroj: Indian Journal of Psychological Medicine
Indian Journal of Psychological Medicine, Vol 42, Iss 1, Pp 61-68 (2020)
ISSN: 0975-1564
0253-7176
Popis: Background: Hematopoietic stem cell transplantation (HSCT) is an established treatment for a number of malignancies. Quality of life (QOL) is an important marker for assessing arduous treatment modalities. Diagnosis of cancer, HSCT, and the physical and psychosocial sequelae of the intensive treatment lead to a deficit in the QOL of the recipient. This study aimed to assess the impact of HSCT on psychiatric morbidity and QOL in patients with hematological malignancies. Methods: A longitudinal pre-post study was conducted at a cancer research center. Thirty patients with hematological malignancies were assessed at three different time points for psychiatric symptoms and QOL. Sociodemographic and clinical variables were collected using a semi-structured questionnaire. Comprehensive psychopathological rating scale was used to assess the psychiatric symptoms. WHO QOL Bref and cancer-specific European Organisation for Research and Treatment of Cancer Quality of life Questionnaire (EORTC-QLQ) were used to measure the quality of life. Results: The mean (SD) age of the sample was 42.3 (12.8) years, with 24 males and 6 females. Most patients reported anxiety and depressive symptoms, reaching a peak at 3 week post-HSCT. The maximum deficit in QOL scores was seen at 3 weeks, with further improvement at 3-month post-transplant. Conclusions: HSCT leads to an increase in symptoms and a decrease in QOL during the acute phase. In the long run, it leads to improvement in physical and psychological wellbeing, with improvement in QOL. The recent surge in the long-term survivors of the procedure calls for further research in this direction so as to aid in their full recovery.
Databáze: OpenAIRE
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