Exercise Preconditioning Attenuates Neurological Injury by Preserving Old and Newly Formed HSP72-Containing Neurons in Focal Brain Ischemia Rats
| Autor: | Ching-Ping Chang, Fong-Chin Su, Cheng Hsien Lin, Kao Chang Lin, Yu Lin Wang, Willy Chou, Chi Chun Chen |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Small interfering RNA HSP72 Heat-Shock Proteins Neuroprotection Brain Ischemia Rats Sprague-Dawley Brain ischemia 03 medical and health sciences chemistry.chemical_compound ischemic brain injury 0302 clinical medicine Physical Conditioning Animal Internal medicine Heat shock protein medicine Animals Humans Exercise Stroke heat shock protein 72 Evans Blue Neurons biology business.industry Brain Infarction Middle Cerebral Artery General Medicine medicine.disease Extravasation Rats Neuroprotective Agents Endocrinology chemistry Brain Injuries biology.protein neuroprotection 030211 gastroenterology & hepatology NeuN business Research Paper |
| Zdroj: | International Journal of Medical Sciences |
| ISSN: | 1449-1907 |
| DOI: | 10.7150/ijms.32962 |
| Popis: | Background: Exercise preconditioning (EP+) is a useful and important procedure for the prevention of stroke. We aimed to ascertain whether EP+ protects against ischemic brain injury by preserving heat shock protein (HSP) 72-containing neurons in ischemic brain tissues. Methods: Adult male Sprague-Dawley rats (n=240) were used to assess the contribution of HSP72-containing neurons to the neuroprotective effects of EP+ on ischemic brain injury caused by transient middle cerebral artery occlusion. Results: Significant (P |
| Databáze: | OpenAIRE |
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