Neutrophil-to-lymphocyte ratio as a predictor of complicated acute diverticulitis: A retrospective cohort study
| Autor: | Florencia Llahi, Agustín E. Pinsak, Alejandro M. Doniquian, René M. Palacios Huatuco, Matías Parodi, Fernando A. Alvarez, Diana A. Pantoja Pachajoa, Nicolás Bruera |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Disease C-reactive protein 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Acute diverticulitis Neutrophil to lymphocyte ratio Neutrophil-to-lymphocyte ratio Cohort Study Predictive marker Receiver operating characteristic biology business.industry fungi Retrospective cohort study General Medicine Surgical procedures 030220 oncology & carcinogenesis biology.protein 030211 gastroenterology & hepatology Surgery business Biomarkers |
| Zdroj: | Annals of Medicine and Surgery |
| ISSN: | 2049-0801 |
| Popis: | Introduction Currently, the debate on the usefulness of Neutrophil to Lymphocyte Ratio (NLR) as a predictor of complications in acute diverticulitis (AD) remains open, especially, the relation to the severity of the disease, the clinical impact, and the necessity of minimally invasive or emergency surgical procedures. On the other hand, its diagnostic efficacy has not been studied even in our field. The objective of the present study was to determine the utility and diagnostic precision of NLR in complicated acute diverticulitis (cAD). Methods Descriptive, retrospective cohort and analytical study. Patients older than 18 years with a diagnosis of AD were included, from 2013 to 2018. Demographic variables, days of hospitalization, leukocyte count, neutrophils, lymphocytes, ESR, CRP, and NLR were analyzed. The sensitivity and specificity for the diagnosis of cAD were determined using ROC curves. Results 325 patients were included. Of these 196 (60%) were men. The median age was 52 years. A total of 30 (9%) were categorized as cAD. The patients with cAD presented mean values in the leukocyte count (14.02 ± 4.49 × 109/l; p Highlights • About 10–15% of patients with acute diverticulitis (AD) can develop complications. • The neutrophil-lymphocyte ratio (NLR) is a useful biomarker in predicting of severity of AD. • The purpose was to determine the usefulness and diagnostic accuracy of NLR in complicated acute diverticulitis (cAD). • An NLR cutoff value ≥ 4.2 was identified as the most appropriate to distinguish cAD. |
| Databáze: | OpenAIRE |
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