Obesity, Type 1 Diabetes, and Psoriasis: An Autoimmune Triple Flip
| Autor: | Evangelia Skarmoutsou, Fabio D’Amico, Mariagrazia Granata, Maria Clorinda Mazzarino, Chiara Trovato, Giulio A. Rossi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adipose Tissue White Autoimmune diseases Adipose tissue Adipokine Inflammation White White adipose tissue Pathology and Forensic Medicine Proinflammatory cytokine 03 medical and health sciences Immune system Adipokines Immunity Psoriasis Diabetes Mellitus Medicine Humans Obesity Molecular Biology business.industry Diabetes MicroRNA Cell Biology General Medicine Cytokines Autoimmune Diseases Diabetes Mellitus Type 1 MicroRNAs medicine.disease 030104 developmental biology Adipose Tissue Immunology medicine.symptom business Type 1 |
| Zdroj: | Europe PubMed Central |
| Popis: | Obesity, type 1 diabetes, and psoriasis are wide-ranging health problems. Genetics, epigenetics, and environmental factors together with immune disturbances are involved in these diseases. The white adipose tissue is an active endocrine organ, secreting a wide variety of soluble mediators called adipokines that have a central role in the relationship between adipose tissue and immune system. Inflammatory cytokines, including the IL-23/IL-17 and IL-18 axes, and microRNAs are involved in many processes, including immunity and inflammation, thus having a major role in the onset of these three diseases. In this review, we present an overview of the roles of adipokines, cytokines, and microRNAs in the pathogenesis and the progression of these three diseases. |
| Databáze: | OpenAIRE |
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