A Comprehensive Review and Perspective on Natural Sources as Dipeptidyl Peptidase-4 Inhibitors for Management of Diabetes
| Autor: | Khurshid Ahmad, Eun-Ju Lee, Sibhghatulla Shaikh, Jeong-Ho Lim, Inho Choi, Syed Sayeed Ahmad |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
dipeptidyl peptidase-4 Pharmaceutical Science Beta-cell Function 030209 endocrinology & metabolism Review Pharmacology 03 medical and health sciences 0302 clinical medicine Pharmacy and materia medica Diabetes mellitus Drug Discovery medicine natural compounds Medicinal plants Dipeptidyl peptidase-4 diabetes business.industry Type 2 Diabetes Mellitus medicine.disease RS1-441 030104 developmental biology Molecular Medicine Medicine business Function (biology) medicinal plants |
| Zdroj: | Pharmaceuticals, Vol 14, Iss 591, p 591 (2021) Pharmaceuticals |
| ISSN: | 1424-8247 |
| Popis: | Type 2 diabetes mellitus (T2DM) is an increasing global public health problem, and its prevalence is expected to rise in coming decades. Dipeptidyl peptidase-4 (DPP-4) is a therapeutic target for the management of T2DM, and its inhibitors prevent the degradation of glucose-dependent insulinotropic peptide and glucagon-like peptide 1, and thus, maintain their endogenous levels and lower blood glucose levels. Various medicinal plant extracts and isolated bioactive compounds exhibit DPP-4 inhibitory activity. In this review, we discussed different natural sources that have been shown to have anti-diabetic efficacy with a particular emphasis on DPP-4 inhibition. Furthermore, the effect of DPP-4 inhibition on pancreatic beta cell function, skeletal muscle function, and the glucose-lowering mechanisms were also discussed. We believe that scientists looking for novel compounds with therapeutic promise against T2DM will be able to develop antidiabetic drugs using these natural sources. |
| Databáze: | OpenAIRE |
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