Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability

Autor:	Bárbara Arévalo, Mauricio Bedoya, Aytug K. Kiper, Fernando Vergara, David Ramírez, Yuliet Mazola, Daniel Bustos, Rafael Zúñiga, Rocio Cikutovic, Angel Cayo, Susanne Rinné, M. Teresa Ramirez-Apan, Francisco V. Sepúlveda, Oscar Cerda, Eduardo López-Collazo, Niels Decher, Leandro Zúñiga, Margarita Gutierrez, Wendy González
Rok vydání:	2022
Předmět:	Models Molecular Structure-Activity Relationship Binding Sites Neoplasms Drug Discovery MCF-7 Cells Molecular Medicine Humans Cell Proliferation
Zdroj:	Journal of medicinal chemistry. 65(22)
ISSN:	1520-4804
Popis:	Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series of compounds based on 3-benzamidobenzoic acid. These compounds block TASK-1 channels by binding to the central cavity. The most active compound is 3-benzoylamino
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443847c04aa0a95094aa8f52a2e9c2ee https://pubmed.ncbi.nlm.nih.gov/36378530 Zobrazit plný text záznamu