Genetics of aryl hydrocarbon hydroxylase induction in mice: Response of the lung to cigarette smoke and 3-methylcholanthrene
| Autor: | John J. Hutton, B. A. Taylor, D. Tomlin, R. K. Abramson |
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| Rok vydání: | 1977 |
| Předmět: |
medicine.medical_specialty
Smoke inhalation medicine.disease_cause Biochemistry Mice Mice Inbred AKR Basal (phylogenetics) chemistry.chemical_compound Inbred strain Internal medicine Tobacco Genetics medicine Animals Enzyme inducer Lung Molecular Biology Ecology Evolution Behavior and Systematics Carcinogen biology Inhalation Smoking General Medicine medicine.disease Mice Inbred C57BL Plants Toxic Endocrinology Genes Liver chemistry Enzyme Induction Immunology Methylcholanthrene biology.protein Hybridization Genetic Aryl Hydrocarbon Hydroxylases Carcinogenesis |
| Zdroj: | Biochemical Genetics. 15:723-740 |
| ISSN: | 1573-4927 0006-2928 |
| DOI: | 10.1007/bf00484100 |
| Popis: | When mice from different inbred strains are injected intraperitoneally with 3-methylcholanthrene (MC), the activity of aryl hydrocarbon hydroxylase (AHH) rapidly increases in livers of some strains but not others. AHH plays a role in the metabolism of polycyclic hydrocarbons. Alleles at a small number of loci account for most of the variation in inducibility of hepatic AHH among mice, when MC is used as the inducing agent. Cigarette smoke is a common source of carcinogenic polycyclic hydrocarbons in the environment. Since some of the hydrocarbons in cigarette smoke are metabolized by AHH, the activity of AHH in tissues may affect the carcinogenicity of smoke in those tissues. The purpose of these experiments was to see whether induction of AHH in lung in response to cigarette smoke is regulated by the same genes that regulate induction of AHH in liver in response to MC. Mouse strains AKR/J and C57L/J and six recombinant inbred (RI) lines derived from them were tested for the response of AHH in lung and liver to parenteral MC or inhalation of cigarette smoke. Inducibility (the ratio of MC-induced AHH activities to basal AHH activities) in liver from MC-treated RI lines is bimodal and compatible with Mendelian segregation of genes at a small number of loci. Increased activities of AHH in MC-treated liver are associated with increased ability to metabolize BP and whole smoke condensates to mutagens detected by Salmonella typhimurium TA1538. Inducibility of AHH in lung in response to MC is not bimodal, and no definite conclusion about the number of loci can be made. When actual levels of AHH activity are considered, following the administration of MC as inducing agent, there is a correlation (r=0.89, p |
| Databáze: | OpenAIRE |
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