Cytoskeletal players in single-cell branching morphogenesis
| Autor: | Sofia J. Araújo, Judith Castro-Ribera, Delia Ricolo |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Nervous system
Neurogenesis Microtúbuls Cell Communication Biology Endoteli Microtubules Dendritic cells 03 medical and health sciences 0302 clinical medicine Microtubule Drosòfila Citosquelet medicine Morphogenesis Animals Humans Endothelium Axon Cytoskeleton Molecular Biology Actin 030304 developmental biology 0303 health sciences Morfogènesi Cell Differentiation Cell Biology Actin cytoskeleton Actins Cell biology Trachea Vesicular transport protein Drosophila melanogaster medicine.anatomical_structure Cèl·lules dendrítiques Drosophila Neuron Single-Cell Analysis 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Dipòsit Digital de la UB Universidad de Barcelona |
| Popis: | Branching networks are a very common feature of multicellular animals and underlie the formation and function of numerous organs including the nervous system, the respiratory system, the vasculature and many internal glands. These networks range from subcellular structures such as dendritic trees to large multicellular tissues such as the lungs. The production of branched structures by single cells, so called subcellular branching, which has been better described in neurons and in cells of the respiratory and vascular systems, involves complex cytoskeletal remodelling events. In Drosophila, tracheal system terminal cells (TCs) and nervous system dendritic arborisation (da) neurons are good model systems for these subcellular branching processes. During development, the generation of subcellular branches by single-cells is characterized by extensive remodelling of the microtubule (MT) network and actin cytoskeleton, followed by vesicular transport and membrane dynamics. In this review, we describe the current knowledge on cytoskeletal regulation of subcellular branching, based on the terminal cells of the Drosophila tracheal system, but drawing parallels with dendritic branching and vertebrate vascular subcellular branching. |
| Databáze: | OpenAIRE |
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