Seroepidemiology of Human Enterovirus 71 Infection among Children, Cambodia

Autor:	Alessio Andronico, Philippe Buchy, Channa Mey, Simon Cauchemez, Arnaud Tarantola, Henrik Salje, Philippe Dussart, Veasna Duong, Paul F. Horwood, Sovann Ly
Přispěvatelé:	Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Modélisation mathématique des maladies infectieuses, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), Ministry of Health [Phnom Penh], GlaxoSmithKline Vaccines [Singapore], GlaxoSmithKline [Headquarters, London, UK] (GSK), This study was supported by the Second Health Sector Support Program, Ministry of Health of the Kingdom of Cambodia, and the Asian Development Bank., Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Salje, Henrik [0000-0003-3626-4254], Apollo - University of Cambridge Repository
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	0301 basic medicine Male Epidemiology encephalitis lcsh:Medicine medicine.disease_cause MESH: Epidemiologic Methods MESH: Estrogens Disease Outbreaks [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Seroepidemiologic Studies Enterovirus 71 Child MESH: Estrone biology seroprevalence enterovirus EV71 Dispatch virus diseases MESH: Climate MESH: China 3. Good health Infectious Diseases MESH: Hawaii Child Preschool MESH: Boston Female MESH: Estradiol MESH: Culture Cambodia Encephalitis Microbiology (medical) Adolescent Virus lcsh:Infectious and parasitic diseases 03 medical and health sciences children medicine Enterovirus Infections Seroprevalence Humans viruses lcsh:RC109-216 MESH: Ovulation MESH: Adolescent MESH: Humans business.industry lcsh:R Outbreak MESH: Adult biology.organism_classification medicine.disease Seroepidemiology of Human Enterovirus 71 Infection among Children Cambodia Virology Enterovirus A Human Human enterovirus 030104 developmental biology Enterovirus [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business MESH: Female MESH: Breast Neoplasms
Zdroj:	Emerging Infectious Diseases, Vol 22, Iss 1, Pp 92-95 (2016) Emerging Infectious Diseases Emerging Infectious Diseases, Centers for Disease Control and Prevention, 2016, 22 (1), pp.92-95. ⟨10.3201/eid2201.151323⟩ Emerging Infectious Diseases, 2016, 22 (1), pp.92-95. ⟨10.3201/eid2201.151323⟩
ISSN:	1080-6059 1080-6040
Popis:	International audience; In a 10-year incidence survey of breast cancer in the City of Boston, 14 cases in American Chinese women were observed, while approximately 13 were expected on the basis of age-specific incidence in the white population. In Hawaii, on the other hand, while breast cancer incidence rates for ethnic Chinese are approximately three times as high as those of indigenous Chinese populations, data indicate that they are still 35% lower than those of whites in Hawaii or on the US mainland. We have compared estrogen concentrations in the urine of Chinese women in the Orient, Honolulu, and Boston. Levels of estrone (E1) and estradiol (E2) increased greatly from the low to the high risk group. The increase was evident among both the younger (15-19 years) and the older (20-24 years) women, in both follicular and luteal phase specimens. The crude unweighted average increase from Oriental to continental US Chinese was about 38% and 34% for E1 and E2, respectively. On the other hand, levels of E3 decreased from the low-risk to the high-risk group, but the decrease was modest (16%) and not always regular. There were no systematic or significant differences in the frequency of ovulation in the three groups of women. These results are compatible with the hypothesis that high levels of estrone and estradiol are important to breast carcinogenesis. Whether E3 has some additional "protective" effect or is irrelevant is unclear. The data do not support the hypothesis that total urine estrogens (E1 + E2 + E3) are predictive of population groups at high risk for breast cancer and they appear inconsistent with the hypothesis that frequency of ovulation (or anovulation) is an important aspect of breast carcinogenesis.
Databáze:	OpenAIRE
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