Assessment of Phytochemical Constituents of Stem Bark Extract of Albizia adianthifolia and its in-vivo Antiplasmodial Activity on Mice infested with Plasmodium berghei
| Autor: | Okoro, I. O. |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Applied Sciences and Environmental Management; Vol. 26 No. 11 (2022); 1873-1880 |
| ISSN: | 2659-1502 1119-8362 1873-1880 |
| DOI: | 10.4314/jasem.v26i11.21 |
| Popis: | Malaria, one of the most debilitating diseases, has a huge impact on large populations in tropical and subtropical areas. Albizia adianthifolia is a perennial evergreen that thrives in moist tropical forest areas. This study intended to assess the phytochemical constituents of stem bark extract of Albizia adianthifolia and its in-vivo antiplasmodial activity on mice infested with Plasmodium berghei. The plant's antimalarial effects at 100, 200 and 400 mg/kg b. wt. dosages against the chloroquine-sensitive strain, Plasmodium berghei were examined using the 4-day suppressive and rane's, tests. In this experiment, 25 mice were classed into five groups (3 treatment and 2 control groups, each with five mice). Parasitaemia, existence time, body mass, and packed cell volume were used to assess the antiplasmodial activity of the extracts. In the 4-day suppression investigation, all doses of the crude extract significantly (P < 0.05) reduced parasitemia, compared to the negative control, with the strongest suppressive effect of 59.93% obtained at dose 400 mg/kg b. wt. Similarly, the Rane's test revealed significant (P |
| Databáze: | OpenAIRE |
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