Metal- and Reagent-Free Anodic C−C Cross-Coupling of Phenols with Benzofurans leading to a Furan Metathesis

Autor:	Siegfried R. Waldvogel, Robert Franke, Bernardo A. Frontana-Uribe, Maurice Dörr, Dieter Schollmeyer, Sebastian Lips
Rok vydání:	2018
Předmět:	010405 organic chemistry Organic Chemistry General Chemistry 010402 general chemistry Electrochemistry Metathesis 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences chemistry.chemical_compound chemistry Furan Reagent Moiety Phenol Phenols Benzofuran
Zdroj:	Chemistry - A European Journal. 24:6057-6061
ISSN:	0947-6539
DOI:	10.1002/chem.201800919
Popis:	Heterobiaryls consisting of a phenol and a benzofuran motif are of significant importance for pharmaceutical applications. An attractive sustainable, metal- and reagent-free, electrosynthetic, and highly efficient method, that allows access to (2-hydroxyphenyl)benzofurans is presented. Upon the electrochemical dehydrogenative C-C cross-coupling reaction, a metathesis of the benzo moiety at the benzofuran occurs. This gives rise to a substitution pattern at the hydroxyphenyl moiety which would not be compatible by a direct coupling process. The single-step protocol is easy to conduct in an undivided electrolysis cell, therefore scalable, and inherently safe.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::443366f48ebcfd127e629363839872d1 https://doi.org/10.1002/chem.201800919 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.