Cytotoxic flavonoids from Erythrina caffra Thunb
| Autor: | Zelalem Yibralign Desta, Norbert Sewald, Runner R. T. Majinda |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Flavonoids
chemistry.chemical_classification biology Traditional medicine Erythrina caffra Cytotoxicity Flavonoid Erythrina caffra Cytotoxicity Antibacterial Flavonoids Fabaceae Fabaceae Biological activity General Chemistry biology.organism_classification lcsh:Chemistry Antibacterial lcsh:QD1-999 chemistry Cytotoxic T cell CERVIX CARCINOMA Antibacterial activity |
| Zdroj: | Bulletin of the Chemical Society of Ethiopia, Vol 30, Iss 3, Pp 427-435 (2017) Bulletin of the Chemical Society of Ethiopia; Vol 30, No 3 (2016); 427-435 |
| ISSN: | 1011-3924 1726-801X |
| DOI: | 10.4314/bcse.v30i3.11 |
| Popis: | Erythrina caffra is an important medicinal plant native to South Africa. Its stem bark was investigated for the flavonoid constituents and biological activity. Some isolated flavonoids, 3 , 5 , 6 , 8 , 9 , 10 , 11 , 12 , 13 , 15 and 16 were found to be active against the human cervix carcinoma KB-3-1 cells with IC 50 values in the micromolar range. Compounds 8 , 9 , 11 , 13 and 15 also showed weak to moderate antibacterial activity against some organisms using the disc diffusion assay at loadings of 62.5 μg/disc ( 8 , 11 ) and 125 μg/disc ( 9 , 13 , 15 ). KEY WORDS : Erythrina caffra , Cytotoxicity, Antibacterial, Flavonoids, Fabaceae Bull. Chem. Soc. Ethiop. 2016 , 30(3), 427-435 DOI: http://dx.doi.org/10.4314/bcse.v30i3.11 |
| Databáze: | OpenAIRE |
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