Control of Alveolar Differentiation by the Lineage Transcription Factors GATA6 and HOPX Inhibits Lung Adenocarcinoma Metastasis
| Autor: | Laura E. Stevens, Minghui Zhao, Paul D. Cao, Thomas F. Westbrook, William K.C. Cheung, Zongzhi Liu, Don X. Nguyen, Justin E. Fang |
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| Rok vydání: | 2013 |
| Předmět: |
endocrine system
Cancer Research Lung Neoplasms Cellular differentiation Adenocarcinoma of Lung Biology Adenocarcinoma medicine.disease_cause Epithelium Article Metastasis 03 medical and health sciences 0302 clinical medicine Cell Line Tumor GATA6 Transcription Factor medicine Cluster Analysis Humans Cell Lineage Neoplasm Invasiveness Neoplasm Metastasis Transcription factor 030304 developmental biology Regulation of gene expression Homeodomain Proteins 0303 health sciences Lung GATA6 Tumor Suppressor Proteins food and beverages Cell Differentiation Cell Biology respiratory system medicine.disease Pulmonary Alveoli medicine.anatomical_structure Gene Expression Regulation Oncology 030220 oncology & carcinogenesis Cancer research Carcinogenesis |
| Zdroj: | Cancer Cell. 23(6):725-738 |
| ISSN: | 1535-6108 |
| DOI: | 10.1016/j.ccr.2013.04.009 |
| Popis: | SummaryMolecular programs that mediate normal cell differentiation are required for oncogenesis and tumor cell survival in certain cancers. How cell-lineage-restricted genes specifically influence metastasis is poorly defined. In lung cancers, we uncovered a transcriptional program that is preferentially associated with distal airway epithelial differentiation and lung adenocarcinoma (ADC) progression. This program is regulated in part by the lineage transcription factors GATA6 and HOPX. These factors can cooperatively limit the metastatic competence of ADC cells, by modulating overlapping alveolar differentiation and invasogenic target genes. Thus, GATA6 and HOPX are critical nodes in a lineage-selective pathway that directly links effectors of airway epithelial specification to the inhibition of metastasis in the lung ADC subtype. |
| Databáze: | OpenAIRE |
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