The probiotic Lactobacillus fermentum 296 attenuates cardiometabolic disorders in high fat diet-treated rats

Autor: Josiane C. Cruz, Valdir A. Braga, Thatyane Mariano Rodrigues de Albuquerque, Raissa Georgianna Silva Cavalcante, Georgianna de Araújo Henriques Ferreira, Marciane Magnani, Lucas Alves Carneiro dos Santos, José Luiz de Brito Alves, Evandro Leite de Souza, Micaelle Oliveira de Luna Freire
Rok vydání: 2019
Předmět:
Blood Glucose
Male
Limosilactobacillus fermentum
medicine.medical_specialty
Lactobacillus fermentum
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Blood lipids
Blood Pressure
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Diet
High-Fat
law.invention
03 medical and health sciences
Probiotic
0302 clinical medicine
Blood serum
Insulin resistance
law
Internal medicine
Lactobacillus
Hyperlipidemia
medicine
Animals
Insulin
Rats
Wistar
Dyslipidemias
Metabolic Syndrome
Nutrition and Dietetics
biology
business.industry
Probiotics
food and beverages
medicine.disease
biology.organism_classification
Lipids
Gastrointestinal Microbiome
Disease Models
Animal
Endocrinology
Hypertension
Dysbiosis
Insulin Resistance
Cardiology and Cardiovascular Medicine
business
Biomarkers
Dyslipidemia
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 29:1408-1417
ISSN: 0939-4753
Popis: Background and aim High-fat (HF) diet consumption has been associated with gut dysbiosis and increased risk of dyslipidemia, type 2 diabetes mellitus and hypertension. Probiotic administration has been suggested as a safe therapeutic strategy for the treatment of cardiometabolic disorders. This study was designed to assess the effects of probiotic Lactobacillus (L.) fermentum 296, a fruit-derived bacteria strain, against cardiometabolic disorders induced by HF diet. Methods and results Male Wistar rats were divided into control diet (CTL); HF diet; and HF diet treated with Lactobacillus fermentum 296 (HF + Lf 296). The L. fermentum 296 strain at 1 × 109 colony forming units (CFU)/ml were daily administered by oral gavage for 4 weeks. The results showed that rats fed with HF diet displayed insulin resistance, reduced Lactobacillus spp. counts in feces, serum lipids, and oxidative profile. Rats fed on HF diet also demonstrated augmented blood pressure associated with sympathetic hyperactivity and impaired baroreflex control. The administration of L. fermentum 296 for 4 weeks recovered fecal Lactobacillus sp. counts and alleviated hyperlipidemia, sympathetic hyperactivity, and reduced systolic blood pressure in HF rats without affecting baroreflex sensibility. Conclusion Our results suggest the ability of L. fermentum 296 improve biochemical and cardiovascular parameters altered in cardiometabolic disorders.
Databáze: OpenAIRE
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