Gender differences in insulin-stimulated glucose utilization among African-Americans
| Autor: | Bonita Falkner, Sonia Hulman, Harvey Kushner |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty medicine.medical_treatment Black People Sex hormone-binding globulin Insulin resistance Sex Factors Internal medicine Blood plasma Internal Medicine medicine Hyperinsulinemia Humans Insulin Testosterone Pancreatic hormone biology Estradiol business.industry Glucose Tolerance Test medicine.disease Endocrinology biology.protein Female Insulin Resistance business Body mass index Hormone |
| Zdroj: | American journal of hypertension. 7(11) |
| ISSN: | 0895-7061 |
| Popis: | The purpose of this study was to determine whether there are gender differences in plasma insulin levels or insulin resistance in young adult African-Americans. Male (n = 53) and female (n = 45) subjects (age 23 to 28 years) included normotensives (N, blood pressure [BP]135/85 mm Hg) and borderline hypertensives (BH, BP135/85 mm Hg). Plasma insulin concentration was measured during an oral glucose tolerance test (OGTT) in all subjects. In 50 cases, insulin clamps were performed. Plasma estradiol and free testosterone were analyzed in a subsample (n = 15) of women. Data were analyzed for BP and gender groups by two-way ANOVA. Compared to men, women in each BP group had higher plasma insulin: glucose ratios (P.01) and sums of insulin on OGTT (P.02). The insulin clamp data also demonstrated significantly lower insulin-stimulated glucose utilization (M) in women compared to men in each BP group (N males 7.28 +/- 0.72 v N females 4.94 +/- 1.2 mg/kg-min; BH males 5.28 +/- .56 v BH females 2.59 +/- 0.50 mg/kg-min; P.004 for gender differences). Analysis of the sex hormone data found a significant correlation in the ratio of free testosterone/estradiol (T/E) with plasma glucose, insulin, insulin/glucose, and systolic BP (P.05), and no correlation of T/E with body mass index or triceps skinfold thickness. These data indicate that there are significant gender differences in plasma insulin levels and in insulin sensitivity in African-Americans. The relationship of plasma insulin to sex hormones suggests that in females, hyperinsulinemia cosegregates with increased androgenicity. |
| Databáze: | OpenAIRE |
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