The Vasodilator Effect of a Cream Containing 10% Menthol and 15% Methyl Salicylate on Random-Pattern Skin Flaps in Rats
| Autor: | Nezih Sungur, Onur Ertunc, Uğur Koçer, Meliha Korkmaz, Ayşe Tülay Bağcı Bosi, Utku Can Dölen, Gökhan Koca |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment lcsh:Surgery Vasodilation Methyl salicylate Scintigraphy chemistry.chemical_compound Medicine Surgical Flaps Saline medicine.diagnostic_test business.industry lcsh:RD1-811 Panniculus carnosus Surgery Perfusion Menthol chemistry Surgical flaps Original Article business Vasodilator agents |
| Zdroj: | Archives of Plastic Surgery, Vol 42, Iss 6, Pp 695-703 (2015) Archives of Plastic Surgery |
| ISSN: | 2234-6171 2234-6163 |
| Popis: | Background It is still difficult to prevent partial or full-thickness flap necrosis. In this study, the effects of a cream containing menthol and methyl salicylate on the viability of randompattern skin flaps were studied. Methods Forty female Sprague-Dawley rats were divided into two equal groups. Caudally based dorsal random-pattern skin flaps were elevated, including the panniculus carnosus. In the study group, 1.5 mL of a cream containing menthol and methyl salicylate was applied to the skin of the flap, and saline solution (0.9%) was used in the control group. Upon completion of the experiment, flap necrosis was analyzed with imaging software and radionuclide scintigraphy. Histopathological measurements were made of the percentage of viable flaps, the number of vessels, and the width of the panniculus carnosus muscle. Results According to the photographic analysis, the mean viable flap surface area in the study group was larger than that in the control group (P=0.004). According to the scintigrams, no change in radioactivity uptake was seen in the study group (P>0.05). However, a significant decrease was observed in the control group (P=0.006). No statistically significant differences were observed between the groups in terms of the percentage of viable flaps, the number of vessels, or the width of the panniculus carnosus muscle (P>0.05). Conclusions Based on these results, it is certain that the cream did not reduce the viability of the flaps. Due to its vasodilatory effect, it can be used as a component of the dressing in reconstructive operations where skin perfusion is compromised. |
| Databáze: | OpenAIRE |
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