Splicing regulation in hematopoiesis
| Autor: | Sisi Chen, Omar Abdel-Wahab |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Transcription Genetic RNA Splicing RNA - Ribonucleic acid Computational biology Biology Article 03 medical and health sciences Splicing factor 0302 clinical medicine Animals Humans Alternative splicing RNA Cell Differentiation Normal hematopoiesis Hematology Hematopoietic Stem Cells Hematopoiesis Haematopoiesis 030104 developmental biology Gene Expression Regulation Mutation RNA splicing RNA Splicing Factors 030215 immunology |
| Zdroj: | Curr Opin Hematol |
| ISSN: | 1531-7048 1065-6251 |
| DOI: | 10.1097/moh.0000000000000661 |
| Popis: | Purpose of review Splicing mutations are among the most recurrent genetic perturbations in hematological malignancies, highlighting an important impact of splicing regulation in hematopoietic development. However, compared to our understanding of splicing factor mutations in hematological malignancies, studies of splicing components and alternative splicing in normal hematopoiesis have been less well investigated. Here, we outline the most recent findings on splicing regulation in normal hematopoiesis and discuss the important questions in the field. Recent findings Recent studies have highlighted the critical role of splicing regulation in hematopoiesis, including characterization of splicing components in normal hematopoiesis, investigation of transcriptional alterations on splicing, and identification of stage-specific alternative splicing events during hematopoietic development. Summary These interesting findings provide insights on hematopoietic regulation at a co-transcriptional level. More high-throughput RNA ribonucleic acid (RNA) sequencing and functional genomic screens are needed to advance our knowledge of critical alternative splicing patterns in shaping hematopoiesis. |
| Databáze: | OpenAIRE |
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