Brief adrenomedullin inhalation leads to sustained reduction of pulmonary artery pressure
| Autor: | E. Schoof, Wolfgang Rascher, Jörg Dötsch, K. Amann, Michael A. Kandler, Martin Chada, K. von der Hardt, A Cubra |
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| Rok vydání: | 2004 |
| Předmět: |
Pulmonary and Respiratory Medicine
Swine Vasodilator Agents Blood Pressure Vasodilation Pulmonary Artery Adrenomedullin medicine.artery Administration Inhalation medicine Animals Inhalation business.industry Respiratory disease Carbon Dioxide medicine.disease Endothelin 1 Pulmonary hypertension Oxygen Blood pressure Anesthesia Models Animal Pulmonary artery Peptides business |
| Zdroj: | European Respiratory Journal. 24:615-623 |
| ISSN: | 1399-3003 0903-1936 |
| DOI: | 10.1183/09031936.04.00016103 |
| Popis: | The effect of aerosolised adrenomedullin (ADM), a potent vasodilator peptide, on pulmonary artery pressure was studied for 24 h in a surfactant-depleted piglet model. Animals received either aerosolised ADM (50 ng.kg(-1).min(-1), ADM, n=6), or aerosolised normal saline solution (control, n=6). Aerosol therapy was performed for a 2 h treatment period followed by a 22 h observation period. Ventilator settings were adapted to keep arterial oxygen tension and carbon dioxide arterial tension between 13.3-14.6 kPa and 4.9-5.7 kPa, respectively. Aerosolised ADM reduced mean pulmonary artery pressure (MPAP) compared with the control group (end-point median 24 h after therapy start: DeltaMPAP -14.0 versus -8.0 mmHg; 23.5 h after therapy start). After therapy start, mean systemic arterial pressure (MAP) was not significantly different between the groups (end-point median: MAP ADM 70 (61/74) versus control 72 (54/81) mmHg). Endothelin-1, a potent pulmonary vasoconstrictor, is regulated by ADM via cAMP. Twenty two hours after inhalation of aerosolised ADM, endothelin-1 mRNA in lung tissue and endothelin-1 protein expression in pulmonary arteries was reduced compared with controls (median semi-quantitative immunhistochemical score: ADM 0.21, control 0.76). Aerosolised adrenomedullin significantly reduced mean pulmonary artery pressure independently of arterial oxygen tension. |
| Databáze: | OpenAIRE |
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