Validity of skin cancer malignancy reporting to the Organ Procurement Transplant Network: A cohort study
| Autor: | Giorgia L. Garrett, Joyce T. Yuan, Thuzar M. Shin, Sarah T. Arron, Oscar Colegio, Clara Curiel, John R. Griffin, Conway C. Huang, Anokhi Jambusaria, Shang I. Brian Jiang, Justin J. Leitenberger, Rajiv I. Nijhawan, Shari Ochoa, Edit B. Olasz, Clark Otley, Arisa Elena Ortiz, Vishal Anil Patel, Melissa Pugliano-Mauro, Chrysalyne D. Schmults, Sarah E. Schram, Thuzar Shin, Seaver Soon, Teresa Soriano, Divya Srivastava, Jennifer Stein, Kara Sternhell-Blackwell, Stan Taylor, Allison Vidimos, Peggy Wu |
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| Rok vydání: | 2017 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty Skin Neoplasms Tissue and Organ Procurement Databases Factual Population Dermatology 030230 surgery Malignancy Organ transplantation Cohort Studies 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Prevalence Humans Registries education Melanoma education.field_of_study business.industry Incidence Odds ratio Organ Transplantation Middle Aged medicine.disease Transplant Recipients United States Cancer registry Surgery Data Accuracy Cohort Carcinoma Squamous Cell Female Skin cancer business Cohort study |
| Zdroj: | Journal of the American Academy of Dermatology. 78(2) |
| ISSN: | 1097-6787 |
| Popis: | Background The Organ Procurement Transplant Network (OPTN) registry collects data on posttransplant malignancies in solid organ transplant recipients. Complete and accurate registry data on skin cancer is critical for research on epidemiology and interventions. Objective The study goal was to determine the validity of Organ Procurement Transplant Network skin cancer data. Methods This cohort study compared reporting of posttransplant squamous cell carcinoma (SCC) and malignant melanoma (MM) in OPTN to medical-record review-derived data from the Transplant Skin Cancer Network (TSCN) database. In total, 4934 organ transplant recipients from the TSCN database were linked to patient-level OPTN malignancy data. We calculated sensitivity, specificity, correct classification (CC), positive predictive value (PPV), and negative predictive value (NPV) for SCC and MM reporting in the OPTN database. Results OPTN reporting for SCC (population prevalence 11%) had sensitivity 41%, specificity 99%, PPV 88%, NPV 93%, and CC 93%. OPTN reporting for MM (population prevalence 1%) had sensitivity 22%, specificity 100%, PPV 73%, NPV 99%, and CC 99%. Limitations Only a subset of patients in the TSCN cohort had matched United Network for Organ Sharing cancer registry data for comparison. Conclusion OPTN reporting had poor sensitivity but excellent specificity for SCC and MM. Dermatologists and transplant physicians are encouraged to improve the validity of OPTN skin cancer data through improved communication and reporting. |
| Databáze: | OpenAIRE |
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