The combination of milatuzumab, a humanized anti-CD74 antibody, and veltuzumab, a humanized anti-CD20 antibody, demonstrates activity in patients with relapsed and refractory B-cell non-Hodgkin lymphoma
| Autor: | William A. Wegener, Robert A. Baiocchi, Kristie A. Blum, Joseph M. Flynn, Mitch A. Phelps, Jeffrey A. Jones, Pierluigi Porcu, Don M. Benson, Lai Wei, Kami J. Maddocks, John C. Byrd, Beth A. Christian, Ming Poi, David M. Goldenberg |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Combination therapy Population Neutropenia Antibodies Monoclonal Humanized Gastroenterology Article chemistry.chemical_compound Refractory Refractory B-Cell Non-Hodgkin Lymphoma hemic and lymphatic diseases Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans education Aged Aged 80 and over B-Lymphocytes education.field_of_study business.industry Lymphoma Non-Hodgkin Hematology Middle Aged Veltuzumab medicine.disease Milatuzumab Treatment Outcome chemistry Immunology Female Rituximab Neoplasm Grading business medicine.drug |
| Zdroj: | Br J Haematol |
| ISSN: | 0007-1048 |
| DOI: | 10.1111/bjh.13354 |
| Popis: | Summary As a result of the anti-tumour activity observed in vitro and in vivo with combined anti-CD20 and anti-CD74 antibodies, we initiated a phase I/II trial of veltuzumab and milatuzumab in patients with relapsed or refractory B-cell non-Hodgkin lymphoma (NHL). Patients received an induction of veltuzumab 200 mg/m2 weekly combined with escalating doses of milatuzumab at 8, 16 and 20 mg/kg weekly for 4 weeks. Patients without disease progression could receive an extended induction with treatment on weeks 12, 20, 28 and 36. A total of 35 patients enrolled on the study. Median age was 63 years, median number of prior therapies was 3, and 63% of patients were rituximab refractory. No dose-limiting toxicities were observed in the phase I study. Related grade 3–4 toxicities included lymphopenia, leucopenia, neutropenia, anaemia, infusion reactions, hyperglycaemia, fatigue and atrial tachycardia. Median weeks of therapy was 12 and 29% of patients completed all 36 weeks of therapy. The overall response rate was 24%, median duration of response was 12 months, and responses were observed at all dose levels and in 50% of patients refractory to rituximab. Combination therapy with veltuzumab and milatuzumab demonstrated activity in a population of heavily pre-treated patients with relapsed or refractory indolent NHL. |
| Databáze: | OpenAIRE |
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