The effects ofN-acetyl-l-cysteine on the female reproductive performance and nephrotoxicity in rats

Autor:	Mona A. M. Helal
Rok vydání:	2016
Předmět:	0301 basic medicine medicine.medical_specialty Kidney Critical Care and Intensive Care Medicine medicine.disease_cause Nephrotoxicity Nitric oxide 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine Animals Rats Wistar NADPH oxidase biology Nicotinamide Super oxide dismutase business.industry Reproduction General Medicine Malondialdehyde Acetylcysteine Rats 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Nephrology biology.protein Female Kidney Diseases business Oxidative stress
Zdroj:	Renal Failure. 38:311-320
ISSN:	1525-6049 0886-022X
DOI:	10.3109/0886022x.2015.1127742
Popis:	This study was designed to investigate whether the treatment with the N-acetyl-L-cysteine prior to the administration of chemotherapy drug would prevent from nephrotoxicity and the loss of reproductive performance induced from chemotherapy treatment. Female rats were divided into five equal groups of six each: 1/control group; 2/rats i.p administered saline solution; 3/rats i.p administered holoxan (50 mg/kg b.wt); 4/rats i.p administered N-acetyl-L-cysteine (160 mg/kg b.wt); 5/rats i.p administered holoxan and N-acetyl-L-cysteine at the same doses. After medications, females rats were allowed to mate with males and the pregnant rats were sacrificed on day 18 of gestation. Premating treatment with holoxan showed reduction (p
Databáze:	OpenAIRE
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