Effect of systemic parathyroid hormone (1-34) and a beta-tricalcium phosphate biomaterial on local bone formation in a critical-size rat calvarial defect model
| Autor: | Jill E. Lewis, Jonathan I. Yun, Frederick C. Bisch, Robert W. Herold, Gary D. Swiec, Ulf M.E. Wikesjö, James C. McPherson, Joseph Wood, James L. Borke |
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| Rok vydání: | 2010 |
| Předmět: |
Calcium Phosphates
Male medicine.medical_specialty Bone Regeneration medicine.medical_treatment Parathyroid hormone chemistry.chemical_element Bone Matrix Calvaria Peptide hormone Calcium Osteotomy Injections Rats Sprague-Dawley Random Allocation Internal medicine medicine Animals Bone Density Conservation Agents business.industry Skull Biomaterial Resorption Rats medicine.anatomical_structure Endocrinology chemistry Parathyroid Hormone Systemic administration Periodontics business |
| Zdroj: | Journal of clinical periodontology. 37(5) |
| ISSN: | 1600-051X |
| Popis: | Yun JI, Wikesjo UME, Borke JL, Bisch FC, Lewis JE, Herold RW, Swiec GD, Wood JC, McPherson III JC. Effect of systemic parathyroid hormone (1–34) and a β-tricalcium phosphate biomaterial on local bone formation in a critical-size rat calvarial defect model. J Clin Periodontol 2010; 37: 419–426 doi: 10.1111/j.1600-051X.2010.01547.x Abstract Objective: The objective of this study was to evaluate local bone formation following systemic administration of parathyroid hormone (1–34) (PTH), a surgically implanted synthetic β-tricalcium phosphate (β-TCP) bone biomaterial serving as a matrix to support new bone formation. Materials and Methods: Critical-size, 8 mm, calvarial through-and-through osteotomy defects were surgically created in 100 adult male Sprague–Dawley rats. The animals were randomized into five groups of 20 animals each to receive one of the following treatments: PTH (15 μg PTH/kg/day; subcutaneously), PTH/β-TCP, β-TCP, or particulate human demineralized freeze-dried bone (DFDB), and sham-surgery controls. Ten animals/group were euthanized at 4 and 8 weeks post-surgery for radiographic and histometric analysis. Results: The histometric analysis showed that systemic PTH significantly enhanced local bone formation, bone fill averaging (±SE) 32.2±4.0% compared with PTH/β-TCP (15.7±2.4%), β-TCP (12.5±2.3%), DFDB (14.5±2.3%), and sham-surgery control (10.0±1.5%) at 4 weeks (p |
| Databáze: | OpenAIRE |
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