Chronic inflammatory bowel disease, deep-venous thrombosis and antithrombin activity
| Autor: | J. McKay, A. Ellis, B.A. McVerry, S. Ghosh, M. Galloway, M.J. Mackie |
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| Rok vydání: | 1983 |
| Předmět: |
medicine.medical_specialty
Antithrombin III Gastroenterology Inflammatory bowel disease Crohn Disease Liver Function Tests Internal medicine medicine Humans alpha-Macroglobulins Colitis Crohn's disease medicine.diagnostic_test business.industry Antithrombin Activity Hematology General Medicine Thrombophlebitis medicine.disease Thrombosis Venous thrombosis Coagulation alpha 1-Antitrypsin Colitis Ulcerative business Liver function tests |
| Zdroj: | Acta haematologica. 70(1) |
| ISSN: | 0001-5792 |
| Popis: | Of 34 patients with chronic inflammatory bowel disease (CIBD), 4 developed well-documented episodes of deep-venous thrombosis. All 4 patients had active disease at the time of thrombosis. This group was studied to determine if the tendency to deep-venous thrombosis in patients with CIBD was associated with reduced antithrombin activity by measuring the concentration of three thrombin inhibitors, antithrombin III (AT III), alpha 2-macroglobulin (alpha 2 M) and alpha 1-antitrypsin. 2 patients had low AT III levels and 10 had low alpha 2 M levels. 2 patients who developed deep-venous thrombosis had significantly low levels of both AT III and alpha 2 M. It is suggested that in patients with diseases predisposing to thrombosis and associated with low AT III levels, the measurement of alpha 2 M in addition to AT III may predict those particularly at risk. |
| Databáze: | OpenAIRE |
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