Characterization of Eosinophilic Bronchiectasis A European Multicohort Study
| Autor: | Amelia Shoemark, Michal Shteinberg, Anthony De Soyza, Charles S. Haworth, Hollian Richardson, Yonghua Gao, Lidia Perea, Alison J. Dicker, Pieter C. Goeminne, Erin Cant, Eva Polverino, Josje Altenburg, Holly R. Keir, Michael R. Loebinger, Francesco Blasi, Tobias Welte, Oriol Sibila, Stefano Aliberti, James D. Chalmers |
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| Přispěvatelé: | Pulmonology, AII - Infectious diseases, Pulmonary medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | American journal of respiratory and critical care medicine, 205(8), 894-902. American Thoracic Society Shoemark, A, Shteinberg, M, de Soyza, A, Haworth, C S, Richardson, H, Gao, Y, Perea, L, Dicker, A J, Goeminne, P C, Cant, E, Polverino, E, Altenburg, J, Keir, H R, Loebinger, M R, Blasi, F, Welte, T, Sibila, O, Aliberti, S & Chalmers, J D 2022, ' Characterization of Eosinophilic Bronchiectasis A European Multicohort Study ', American Journal of Respiratory and Critical Care Medicine, vol. 205, no. 8, pp. 894-902 . https://doi.org/10.1164/RCCM.202108-1889OC American Journal of Respiratory and Critical Care Medicine, 205(8), 894-902. American Thoracic Society |
| ISSN: | 1073-449X |
| Popis: | Rationale: Bronchiectasis is classically considered a neutrophilic disorder, but eosinophilic subtypes have recently been described. Objectives: To use multiple datasets available through the European Multicentre Bronchiectasis Audit and Research Collaboration to characterize eosinophilic bronchiectasis as a clinical entity focusing on the impact of eosinophils on bronchiectasis exacerbations. Methods: Patients were included from five countries to examine the relationships between blood eosinophil counts and clinical phenotypes after excluding coexisting asthma. 16S rRNA sequencing was used to examine relationships between eosinophil counts and the sputum microbiome. A post hoc analysis of the PROMIS (Inhaled Promixin in the Treatment of Non–Cystic Fibrosis Bronchiectasis) phase 2 trial was used to examine the impact of blood eosinophil counts on exacerbations in patients with Pseudomonas aeruginosa infection. Measurements and Main Results: A relationship between sputum and blood eosinophil counts was demonstrated in two cohorts. In analysis of 1,007 patients from five countries, 22.6% of patients had blood eosinophil counts of ≽300 cells/μl. Counts of |
| Databáze: | OpenAIRE |
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