Differential Roles of Interleukin-17A and -17F in Host Defense against Mucoepithelial Bacterial Infection and Allergic Responses
| Autor: | Aya Nambu, Yutaka Komiyama, Katsuko Sudo, Susumu Nakae, Hayato Kotaki, Harumichi Ishigame, Yuko Tanahashi, Takeshi Nagai, Shigeru Kakuta, Yoichiro Iwakura, Motohiko Kadoki, Noriyuki Fujikado, Aoi Akitsu, Chihiro Sasakawa |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_treatment
Immunology Arthritis Biology Mice Immune system Hypersensitivity medicine Animals Immunology and Allergy MOLIMMUNO Receptor Cells Cultured Mice Knockout Innate immune system Interleukin-17 Bacterial Infections Flow Cytometry medicine.disease IL 17 family Infectious Diseases Cytokine CELLIMMUNO Cytokines IL17A Interleukin 17 |
| Zdroj: | Immunity. 30:108-119 |
| ISSN: | 1074-7613 |
| Popis: | Interleukin-17A (IL-17A) is a cytokine produced by T helper 17 (Th17) cells and plays important roles in the development of inflammatory diseases. Although IL-17F is highly homologous to IL-17A and binds the same receptor, the functional roles of this molecule remain largely unknown. Here, we demonstrated with Il17a(-/-), Il17f(-/-), and Il17a(-/-)Il17f(-/-) mice that IL-17F played only marginal roles, if at all, in the development of delayed-type and contact hypersensitivities, autoimmune encephalomyelitis, collagen-induced arthritis, and arthritis in Il1rn(-/-) mice. In contrast, both IL-17F and IL-17A were involved in host defense against mucoepithelial infection by Staphylococcus aureus and Citrobacter rodentium. IL-17A was produced mainly in T cells, whereas IL-17F was produced in T cells, innate immune cells, and epithelial cells. Although only IL-17A efficiently induced cytokines in macrophages, both cytokines activated epithelial innate immune responses. These observations indicate that IL-17A and IL-17F have overlapping yet distinct roles in host immune and defense mechanisms. |
| Databáze: | OpenAIRE |
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