Impact of chronic wounds of various etiology on systemic profiles of key inflammatory cytokines, chemokines and growth factors, and their interplay
| Autor: | Sylwia Płaczkowska, Leszek Masłowski, Magdalena Mierzchala, Andrzej Gamian, Iwona Bednarz-Misa, Małgorzata Gacka, Agnieszka Bronowicka-Szydełko, Małgorzata Krzystek-Korpacka, Joanna Kubiak, Krzysztof Kędzior |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Vascular Endothelial Growth Factor A 030213 general clinical medicine Chemokine Medicine (miscellaneous) Inflammation Disease General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Venous stasis 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal Medicine medicine Humans Pharmacology (medical) Prospective Studies Genetics (clinical) Aged Aged 80 and over Wound Healing biology business.industry Odds ratio Middle Aged medicine.disease Case-Control Studies Chronic Disease Reviews and References (medical) Immunology Etiology biology.protein Cytokines Intercellular Signaling Peptides and Proteins Female Chemokines medicine.symptom business Biomarkers |
| Zdroj: | Advances in Clinical and Experimental Medicine. 28:1301-1309 |
| ISSN: | 1899-5276 |
| DOI: | 10.17219/acem/103845 |
| Popis: | Background Non-healing wounds are becoming a growing concern for public health as a result of their increasing prevalence in progressively aging societies. Objectives The aim of this article is to evaluate the effects of wound etiology on a panel of circulating cytokines in patients with non-healing wounds of the lower extremities. Material and methods This prospective case-control study involved 104 individuals: healthy elderly people (n = 46) and patients with diabetes and/or cardiovascular disease (n = 58; among them 38 with chronic wounds of venous, ischemic or neurotrophic etiology). Selected serum cytokines - i.e. IL-1β, IL-4, IL-6, IL-8, FGF-2, G-CSF, GM-CSF, MCP-1, MIP-1α, TNF-α, VEGF-A, and PDGF-BB - were measured using the Luminex platform. Results Compared to healthy elderly people, presence of diabetes and/or cardiovascular disease was associated with elevated IL-6, IL-8, MCP-1 and G-CSF while non-healing wounds coexisted with the increase in the levels of all examined cytokines/growth factors except for G-CSF and GM-CSF. Among diseased elderly people, having wounds was associated with increased levels of IL-1β, IL-4, IL-6, IL-8, FGF-2, MIP-1α, PDGF-BB, and VEGF-A. Interleukin 1β elevation was a sole independent predictor of chronic wounds with an odds ratio (OR) of 6.3. Cytokines in healthy seniors were loosely interrelated, while the levels of cytokines in diseased patients with wounds displayed a tight pattern of association. When stratified by their etiology, the association pattern for IL-6, IL-8, MCP-1, and VEGF-A was disrupted in neurotrophic wounds. Conclusions The results presented herein may improve our understanding of the pathomechanisms which lead to chronic wounds and of the effects they exert on a systemic level, as well as providing potential targets for more effective therapies. |
| Databáze: | OpenAIRE |
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