Recent advances in viral evasion of the MHC Class I processing pathway
| Autor: | Anouk B. C. Schuren, Emmanuel J. H. J. Wiertz, Ana I. Costa |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Cytotoxicity
Immunologic 0301 basic medicine viruses T cell Immunology Antigen presentation chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes Major histocompatibility complex 03 medical and health sciences 0302 clinical medicine Immune system Antigen MHC class I medicine Animals Humans Immunology and Allergy Antigens Viral Immune Evasion Antigen Presentation biology Histocompatibility Antigens Class I Evasion (ethics) Acquired immune system Killer Cells Natural 030104 developmental biology medicine.anatomical_structure Gene Expression Regulation Virus Diseases Viruses biology.protein 030215 immunology |
| Zdroj: | Current Opinion in Immunology. 40:43-50 |
| ISSN: | 0952-7915 |
| Popis: | T-cell mediated adaptive immunity against viruses relies on recognition of virus-derived peptides by CD4(+) and CD8(+) T cells. Detection of pathogen-derived peptide-MHC-I complexes triggers CD8(+) T cells to eliminate the infected cells. Viruses have evolved several mechanisms to avoid recognition, many of which target the MHC-I antigen-processing pathway. While many immune evasion strategies have been described in the context of herpesvirus infections, it is becoming clear that this 'disguise' ability is more widespread. Here, we address recent findings in viral evasion of the MHC-I antigen presentation pathway and the impact on CD8(+) T cell responses. |
| Databáze: | OpenAIRE |
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