Lbx1 acts as a selector gene in the fate determination of somatosensory and viscerosensory relay neurons in the hindbrain
| Autor: | Elena Vasyutina, Hagen Wende, Katja Reuter, Margaret Martinez-de-la-Torre, Martin A. Sieber, Carmen Birchmeier, Thomas Müller, Robert Storm |
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| Rok vydání: | 2007 |
| Předmět: |
Genetic Linkage
Visceral Afferents Muscle Proteins Hindbrain Biology Somatosensory system law.invention Mice Relay law medicine Animals Neurons Afferent Gene Neurons General Neuroscience Spinal trigeminal nucleus Genes Homeobox Articles Mice Mutant Strains Rhombencephalon medicine.anatomical_structure nervous system embryonic structures Homeobox Function and Dysfunction of the Nervous System Neuroscience |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1529-2401 |
| Popis: | Distinct types of relay neurons in the hindbrain process somatosensory or viscerosensory information. How neurons choose between these two fates is unclear. We show here that the homeobox geneLbx1is essential for imposing a somatosensory fate on relay neurons in the hindbrain. InLbx1mutant mice, viscerosensory relay neurons are specified at the expense of somatosensory relay neurons. Thus Lbx1 expression distinguishes between the somatosensory or viscerosensory fate of relay neurons. |
| Databáze: | OpenAIRE |
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