Prognostic Value of Natural Killer Cells Besides Tumor-Infiltrating Lymphocytes in Breast Cancer Tissues
Autor: | Boutheina Cherif, Lobna Bouzidi, Hana Triki, Slim Charfi, Wala Ben Kridis, Lobna Ayadi, Mohamed Derbel, Tahya Sellami-Boudawara |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Adult Cancer Research Estrogen receptor Breast Neoplasms Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Immune system Breast cancer Lymphocytes Tumor-Infiltrating Biomarkers Tumor Medicine Humans Pathological High-power field business.industry Tumor-infiltrating lymphocytes Middle Aged medicine.disease Prognosis Immunohistochemistry Killer Cells Natural 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research Female business Infiltration (medical) |
Zdroj: | Clinical breast cancer. 21(6) |
ISSN: | 1938-0666 |
Popis: | Background Each subgroup of immune cells has a different prognostic role in breast cancer; however, the prognostic impact of tumor-infiltrating natural killer cells (TINKs) is still not well established. Our aim was to assess the prognostic impact of natural killer (NK) cells in breast carcinomas. Materials and Methods NK cells infiltration were assessed by immunohistochemistry (IHC). Statistical analyses were performed to evaluate the correlation of NK cells with clinical-pathological features and outcome. Results CD56 IHC was realized in 126 patients. NK cells infiltration showed significant and positive association with tumor high Scarff-Bloom-Richardson (SBR) grade. NK cells were significantly associated with HER2-positive breast cancer and triple-negative breast cancer subtypes. Analyses showed significant and inverse correlation with progesterone and estrogen receptors expression status. High NK cells were significantly related to high Ki-67 labeling index. Our data showed that high NK cells infiltrate was significantly associated with tumor-infiltrating lymphocytes in breast cancer tissues. At a median follow-up of 5.5 years, high CD56 expression (≥ 5 cells/10 high power field) was associated significantly with a good overall survival and with good disease-free survival. Conclusion In this study, we assessed the important prognostic role of TINKs in breast carcinomas, which seems to be evident despite its association with aggressive pathological features. Thus evaluation of NK cells can be standardized and integrated in daily routine. |
Databáze: | OpenAIRE |
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