Diagnostic and treatment hurdles in plasma cell myeloma with t(11;14) translocation: A case report

Autor:	Shun Yin Kong, Yiu Ming Yeung, Ho Kei Lai, Wing Kit Lam, Sze Fai Yip, Ka Shu Li, Chung Yin Ha, Hay Nun Chan, Ka Pik Yeung
Rok vydání:	2018
Předmět:	Cancer Research Vincristine Oncogene business.industry Bortezomib Cell Chromosomal translocation Articles Cell cycle medicine.anatomical_structure Oncology hemic and lymphatic diseases Plasma Cell Myeloma medicine Cancer research business Dexamethasone medicine.drug
Zdroj:	Molecular and Clinical Oncology.
ISSN:	2049-9469 2049-9450
DOI:	10.3892/mco.2018.1612
Popis:	t(11;14) translocation is one of the most common chromosomal abnormalities in plasma cell myeloma. The present case report presented a case of plasma cell myeloma with t(11;14) translocation, in which the plasma cells were small lymphoplasmacytoids in morphology with positive cluster of differentiation-20 and Cyclin D1 expression. These results led to initial diagnostic difficulties. The patient was refractory to bortezomib-based therapy, and responsive to vincristine, doxorubicin and dexamethasone. However, the prognostic value of t(11;14) in plasma cell myeloma remains to be determined. With recent advances in treatment options, physicians should be aware of the clinical and pathological characteristics of this translocation in plasma cell myeloma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4417c6ad0da0a56c072d5b5f16824cbd https://doi.org/10.3892/mco.2018.1612 Zobrazit plný text záznamu