Beyond the NCCN Risk Factors in Colon Cancer : An Evaluation in a Swedish Population-Based Cohort
| Autor: | Bengt Glimelius, Artur Mezheyeuski, Erik Osterman, Tobias Sjöblom |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male medicine.medical_specialty Colorectal cancer 03 medical and health sciences 0302 clinical medicine Carcinoembryonic antigen Swedish population Surgical oncology Risk Factors Internal medicine medicine Humans Prospective Studies Prospective cohort study 030304 developmental biology Aged Neoplasm Staging Proportional Hazards Models Aged 80 and over Sweden Colorectal Cancer 0303 health sciences Cancer och onkologi biology business.industry Hazard ratio Klinisk medicin Middle Aged medicine.disease Prognosis Carcinoembryonic Antigen C-Reactive Protein Time to recurrence 030220 oncology & carcinogenesis Lymphatic Metastasis Cancer and Oncology Cohort Colonic Neoplasms biology.protein Lymph Node Excision Surgery Female Lymph Nodes Neoplasm Recurrence Local Clinical Medicine business |
| Zdroj: | Annals of Surgical Oncology |
| Popis: | Background The purpose of this study was to investigate whether pT3–4 and pN-subclassifications, lymph-node ratio (LNR), tumour deposits, pre- and postoperative carcinoembryonic antigen (CEA), and C-reactive protein (CRP)—all parameters commonly collected in clinical management—add information about recurrence risk against a background of routine clinicopathological parameters as defined by the NCCN. Methods The prospective cohort consisted of all 416 patients diagnosed with colon cancer stage I–III in Uppsala County between 2010 and 2015. Cox proportional hazard models were used to calculate hazard ratios for time to recurrence and overall survival. The results were compared with the entire Swedish population concerning parameters recorded in the national quality registry, SCRCR, during the same time period. Results The Uppsala cohort was representative of the entire Swedish cohort. In unadjusted analyses, pT3-subclassification, pN-subclassification, LNR, tumour deposits, elevated postoperative CEA, and preoperative CRP correlated with recurrence. After adjusting for T-, N-stage, and NCCN risk factors, pN-subclassification, sidedness, and elevated postoperative CEA levels correlated with recurrence. Survival correlated with parameters associated with recurrence, LNR, and elevated postoperative CRP. Conclusions Additional information on recurrence risk is available from several routinely recorded parameters, but most of the risk is predicted by the commonly used clinicopathological parameters. |
| Databáze: | OpenAIRE |
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