DNA loop anchorage region colocalizes with the replication origin located downstream to the human gene encoding lamin B2

Autor: Mauro Giacca, Arturo Falaschi, Ekaterina Svetlova, Maria A. Lagarkova, Sergey V. Razin
Přispěvatelé: M. A., Lagarkova, E., Svetlova, Giacca, Mauro, A., Falaschi, S. V., Razin
Rok vydání: 1998
Předmět:
DNA Replication
metabolism
DNA
Eukaryotic DNA replication
HL-60 Cells
Replication Origin
genetics
DNA Topoisomerase
Biochemistry
Type II
DNA replication factor CDT1
Control of chromosome duplication
genetics
Nucleic Acid Conformation
Replication Origin
Humans
genetics
chemistry/genetics/metabolism
Genome
chemistry/genetics/metabolism
Molecular Biology
Gene
Human
HL-60 Cells
Humans
Lamin Type B
Lamins
Nuclear Protein
Genome
Binding Sites
biology
Lamin Type B
Genome
Human
Topoisomerase
DNA replication
Binding Site
Chromosome Mapping
Nuclear Proteins
genetics
Chromosome Mapping
DNA Replication
genetics
DNA Topoisomerases
Human
HL-60 Cells
Humans
Lamin Type B
Lamins
Nuclear Proteins
Cell Biology
DNA
Molecular biology
Lamins
DNA Topoisomerases
Type II
biology.protein
Origin recognition complex
Nucleic Acid Conformation
Human genome
metabolism
DNA Topoisomerases
Human
Zdroj: Journal of cellular biochemistry. 69(1)
ISSN: 0730-2312
Popis: The recently developed procedure of topoisomerase II-mediated DNA loop excision has been used to analyze the topological organization of a human genome fragment containing the gene encoding lamin B2 and the ppv1 gene. A 3.5 kb long DNA loop anchorage/topoisomerase II cleavage region was found within the area under study. This region includes the end of the lamin B2 coding unit and an intergenic region where an origin of DNA replication was previously found. These observations further corroborate the hypothesis that DNA replication origins are located at or close to DNA loop anchorage regions. J. Cell. Biochem. 69:13-18, 1998. r 1998 Wiley-Liss, Inc.
Databáze: OpenAIRE
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