Integration of luminal pressure and signalling in tissue self-organization
| Autor: | Chii J. Chan, Takashi Hiiragi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Hydrostatic pressure
Cellular functions Morphogenesis Embryonic Development Biology Cell fate determination Mechanotransduction Cellular Models Biological 03 medical and health sciences 0302 clinical medicine Osmotic Pressure Signalling molecules Hydrostatic Pressure Animals Humans Tissue mechanics Molecular Biology 030304 developmental biology Self-organization 0303 health sciences Cell Differentiation Biomechanical Phenomena Signalling Stress Mechanical Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Development |
| ISSN: | 0950-1991 |
| DOI: | 10.1242/dev.181297 |
| Popis: | Many developmental processes involve the emergence of intercellular fluid-filled lumina. This process of luminogenesis results in a build up of hydrostatic pressure and signalling molecules in the lumen. However, the potential roles of lumina in cellular functions, tissue morphogenesis and patterning have yet to be fully explored. In this Review, we discuss recent findings that describe how pressurized fluid expansion can provide both mechanical and biochemical cues to influence cell proliferation, migration and differentiation. We also review emerging techniques that allow for precise quantification of fluid pressure in vivo and in situ. Finally, we discuss the intricate interplay between luminogenesis, tissue mechanics and signalling, which provide a new dimension for understanding the principles governing tissue self-organization in embryonic development. |
| Databáze: | OpenAIRE |
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