Curcumin/xanthan-galactomannan hydrogels: rheological analysis and biocompatibility
| Autor: | Eneida Janiscki Da-Lozzo, Ricardo Cambaúva Andrukaisti Moledo, Joana Léa Meira Silveira, Cloris D. Faraco, Claudia Feijó Ortolani-Machado, Tania Mari Bellé Bresolin |
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| Rok vydání: | 2011 |
| Předmět: |
Curcumin
Polymers and Plastics Biocompatibility Administration Topical Neovascularization Physiologic Biocompatible Materials Chick Embryo Viscoelastic Substances Polysaccharide Galactans Chorioallantoic Membrane Mannans chemistry.chemical_compound Materials Testing Plant Gums Materials Chemistry Animals Curcuma chemistry.chemical_classification biology Chemistry Organic Chemistry Polysaccharides Bacterial Galactose Biological activity Hydrogels biology.organism_classification Bioavailability Chorioallantoic membrane Self-healing hydrogels Biophysics Rheology |
| Zdroj: | Carbohydrate polymers. 93(1) |
| ISSN: | 1879-1344 |
| Popis: | Curcumin, a lipophilic compound found in the plant Curcuma longa L., exhibits a wide range of pharmacological activity; however, its therapeutic use has been limited because of its low bioavailability following oral administration. The aim of this study was to evaluate the viscoelastic characteristics and biocompatibility of a curcumin/xanthan:galactomannan hydrogel (X:G) system after topical application on chick embryo chorioallantoic membrane (CAM), a system established with a view toward curcumin nasal or topical pharmaceutical applications or possible administration in cosmetics or foods. A rheological analysis indicated that incorporation of curcumin did not alter the viscoelastic characteristics of the X:G hydrogel, suggesting that there was no change in the structure of the gel network. X:G hydrogels did not induce CAM tissue injury and the curcumin/X:G hydrogel system was also highly biocompatible. We conclude that the X:G hydrogel represents a potential matrix for curcumin formulations. |
| Databáze: | OpenAIRE |
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