Antibodies to Epstein-Barr Virus in Patients with Nasopharyngeal Carcinoma and in Comparison Groups
| Autor: | Gary R. Pearson, William F. Taylor, H. Bryan Neel |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Herpesvirus 4
Human Fluorescent Antibody Technique Antibodies Viral medicine.disease_cause Serology 03 medical and health sciences Capsid 0302 clinical medicine Antigen otorhinolaryngologic diseases Carcinoma medicine Humans Nasal polyps Prospective Studies 030223 otorhinolaryngology Antigens Viral biology business.industry Nasopharyngeal Neoplasms General Medicine medicine.disease Epstein–Barr virus Immunoglobulin A Squamous carcinoma stomatognathic diseases Otorhinolaryngology Nasopharyngeal carcinoma Head and Neck Neoplasms Immunoglobulin G 030220 oncology & carcinogenesis Immunology Carcinoma Squamous Cell biology.protein Antibody business |
| Zdroj: | Annals of Otology, Rhinology & Laryngology. 93:477-482 |
| ISSN: | 1943-572X 0003-4894 |
| DOI: | 10.1177/000348948409300513 |
| Popis: | One hundred fifty-one patients with nasopharyngeal carcinoma (NPC) were enrolled in a prospective collaborative study of North American patients (most were white). Serum samples were collected concurrently from 903 Mayo patients for comparisons of serologic analyses. Both IgA antiviral capsid antigen [VCA (IgA)] and the anti-early antigen [EA (D)] antibody responses were associated with diagnosis, but not always in the same way. Both responses were positive in 85% of patients with World Health Organization types 2 and 3 NPC. Only 16 % with WHO type 1 NPC had positive IgA responses and only 35% had positive EA (D) responses, prevalences close to those in the comparison groups. Increased titers were found in the squamous carcinoma comparison group with tumors of the tongue and in the group with benign nasal polyps (p |
| Databáze: | OpenAIRE |
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