Vanadyl sulfate treatment improves oxidative stress and increases serum paraoxonase activity in streptozotocin-induced diabetic rats
| Autor: | Emre Sarandol, Zehra Serdar, Sedef Ziyanok-Ayvalik, Melahat Dirican, Nihal Ocak, Sibel Tas |
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| Přispěvatelé: | Uludağ Üniversitesi/Fen Edebiyet Fakültesi/Biyoloji Bölümü., Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı., Taş, Sibel, Sarandöl, Emre, Ziyanok, Sedef Ayvalık, Ocak, Nihal, Serdar, Zehra, Dirican, Melahat, ABE-6873-2020, ABE-1716-2020, AAG-6985-2021, AAH-6200-2021 |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
Dug inhibition Endocrinology Diabetes and Metabolism Glucose blood level Randomization medicine.disease_cause Animal tissue Lipid peroxidation chemistry.chemical_compound Plasma Endocrinology Aminoguanidine Insulin Enzyme activity Treatment outcome Disease course Priority journal Antioxidant status Species comparison Nutrition and Dietetics biology Streptozotocin Diabetes Malonaldehyde Glucose autoxidation Lipid Malondialdehyde Lipid-peroxidation Aryldialkylphosphatase Paraoxonase Insulin blood level Autoxidative glycosylation medicine.drug Vitamin blood level medicine.medical_specialty Carbohydrate Superoxide dismutase Streptozocin Article LDL Bis(Acetylacetonato)Oxovanadium(IV) Vanadium Compounds Oxovanadium IV Antioxidant activity In-vivo Diabetes mellitus Internal medicine medicine Drinking water Animal model Animal experiment Nutrition & dietetics Vanadyl sulfate Mellitus Alpha tocopherol Coronary artery atherosclerosis medicine.disease Nonhuman Rattus norvegicus Lipid blood level Therapy effect Drug effect Glucose chemistry Oxidative stress Susceptibility Streptozocin diabetes biology.protein Glutathione peroxidase Rat Diabetogenesis Controlled study Enzyme blood level |
| Popis: | Vanadyl sulfate (VS) may reduce oxidative stress related to its hypoglycemic and hypolipidemic effects in diabetes mellitus; besides, as a catalytic element, it may induce lipid peroxidation. Studies investigating effects of VS on the oxidative-antioxidative systems in diabetes yielded conflicting results, and this study was designed to investigate the effects of VS on the oxidative-antioxidative systems in streptozotocin-induced (65 mg/kg) diabetic rats. Vanadyl sulfate was administered in drinking water 0.75 mg/mL during 5 weeks after the induction of diabetes. Thirty-two male Wistar rats were randomly divided into four groups: control (C), control + vanadyl sulfate (C + VS), diabetes (D), and diabetes + vanadyl sulfate (D + VS). Vanadyl sulfate reduced the enhanced glucose, lipid, and tissue malondialdehyde levels and increased the reduced serum paraoxonase and arylesterase activity in the D + VS group. Plasma malondialdehyde level was significantly increased in the C + VS group, compared with the control group. Erythrocyte glutathione peroxidase activity was significantly higher in the C + VS and D + VS groups, compared with the C and the D groups, respectively.The results of the present study suggest that (i) VS has antioxidative potential in streptozotocin-treated rats, and it might be used as a supportive therapeutic agent in uncontrolled diabetes; (ii) VS treatment might play a role in the improvement of serum paraoxonase activity and, thus, inhibit the progression of atherosclerosis; (iii) the prooxidant potential of the VS should be taken into account. |
| Databáze: | OpenAIRE |
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