Rationale and study design of the Japan environment and children's study (JECS)
| Autor: | Hiroshi Satoh, Reiko Kishi, Manabu Hasegawa, Ayano Takeuchi, Katsuyuki Murata, Yasuyuki Shibata, Shoji F. Nakayama, Yuji Koresawa, Naoya Tsukamoto, Zentaro Yamagata, Haruhiko Sago, Takehiro Michikawa, Susumu Yokoya, Toshihiro Kawamoto, Fujio Kayama, Hiroshi Nitta, Tsutomu Ogata, Makiko Okuyama, Yukihiro Ohya, Hirohisa Saito, Eisaku Toda |
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| Rok vydání: | 2013 |
| Předmět: |
Research design
Adult Male medicine.medical_specialty Adolescent Child Welfare Environment Cohort Studies Study Protocol Japan Pregnancy Environmental health Epidemiology medicine Humans Computer Simulation Early childhood Longitudinal Studies Child Socioeconomic status Children Family Characteristics Milk Human business.industry Public health Pregnant women Public Health Environmental and Occupational Health Infant Newborn Infant Environmental Exposure Fetal Blood Growth and development Pregnancy Complications Environmental chemicals Maternal Exposure Research Design Child Preschool Environmental Pollutants Female Biostatistics Risk assessment business Biomarkers Birth cohort Cohort study Hair |
| Zdroj: | BMC Public Health |
| ISSN: | 1471-2458 |
| Popis: | Background There is global concern over significant threats from a wide variety of environmental hazards to which children face. Large-scale and long-term birth cohort studies are needed for better environmental management based on sound science. The primary objective of the Japan Environment and Children’s Study (JECS), a nation-wide birth cohort study that started its recruitment in January 2011, is to elucidate environmental factors that affect children’s health and development. Methods/Design Approximately 100,000 expecting mothers who live in designated study areas will be recruited over a 3-year period from January 2011. Participating children will be followed until they reach 13 years of age. Exposure to environmental factors will be assessed by chemical analyses of bio-specimens (blood, cord blood, urine, breast milk, and hair), household environment measurements, and computational simulations using monitoring data (e.g. ambient air quality monitoring) as well as questionnaires. JECS’ priority outcomes include reproduction/pregnancy complications, congenital anomalies, neuropsychiatric disorders, immune system disorders, and metabolic/endocrine system disorders. Genetic factors, socioeconomic status, and lifestyle factors will also be examined as covariates and potential confounders. To maximize representativeness, we adopted provider-mediated community-based recruitment. Discussion Through JECS, chemical substances to which children are exposed during the fetal stage or early childhood will be identified. The JECS results will be translated to better risk assessment and management to provide healthy environment for next generations. |
| Databáze: | OpenAIRE |
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