nuScore: a web-interface for nucleosome positioning predictions
| Autor: | Victor B. Zhurkin, Wilma K. Olson, Michael Y. Tolstorukov, Vidhu Choudhary, Peter J. Park |
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| Rok vydání: | 2008 |
| Předmět: |
Statistics and Probability
Molecular Sequence Data Sequence alignment Biochemistry Article World Wide Web User-Computer Interface Software Nucleosome Computer Simulation Molecular Biology Internet biology Base Sequence Models Genetic business.industry Chromosome Mapping Sequence Analysis DNA Computer Science Applications Nucleosomes Computational Mathematics Histone Template Computational Theory and Mathematics Energy cost biology.protein Threading (protein sequence) User interface business Algorithm Sequence Alignment Algorithms |
| Zdroj: | Bioinformatics (Oxford, England). 24(12) |
| ISSN: | 1367-4811 |
| Popis: | Summary: Sequence-directed mapping of nucleosome positions is of major biological interest. Here, we present a web-interface for estimation of the affinity of the histone core to DNA and prediction of nucleosome arrangement on a given sequence. Our approach is based on assessment of the energy cost of imposing the deformations required to wrap DNA around the histone surface. The interface allows the user to specify a number of options such as selecting from several structural templates for threading calculations and adding random sequences to the analysis. Availability: The nuScore interface is freely available for use at http://compbio.med.harvard.edu/nuScore. Contact: peter_park@harvard.edu; tolstorukov@gmail.com Supplementary information: The site contains user manual, description of the methodology and examples. |
| Databáze: | OpenAIRE |
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