Deep-brain stimulation of the subthalamic nucleus improves overriding motor actions in Parkinson's disease
| Autor: | Theodore R. Bashore, Wery P. M. van den Wildenberg, Nelleke C. van Wouwe, Joseph S. Neimat, W. Jeffrey Elias, Scott A. Wylie, K. Richard Ridderinkhof |
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| Přispěvatelé: | Ontwikkelingspsychologie (Psychologie, FMG) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Deep brain stimulation Parkinson's disease Deep Brain Stimulation medicine.medical_treatment Stimulation Motor Activity Audiology Task (project management) Executive Function 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Subthalamic Nucleus Healthy control Humans Medicine Aged 030304 developmental biology 0303 health sciences business.industry Parkinson Disease Middle Aged Voluntary action medicine.disease Inhibition Psychological Subthalamic nucleus Treatment Outcome Female sense organs business Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Behavioural Brain Research, 402:113124. Elsevier |
| ISSN: | 0166-4328 |
| DOI: | 10.1016/j.bbr.2021.113124 |
| Popis: | Findings from previous research using the classic stop-signal task indicate that the subthalamic nucleus (STN) plays an important role in the ability to inhibit motor actions. Here we extend these findings using a stop-change task that requires voluntary action override to stop an ongoing motor response and change to an alternative response. Sixteen patients diagnosed with Parkinson's disease (PD) and 16 healthy control participants (HC) performed the stop-change task. PD patients completed the task when deep-brain stimulation (DBS) of the STN was turned on and when it was turned off. Behavioral results indicated that going, stopping, and changing latencies were shortened significantly among PD patients during STN DBS, the former two reductions replicating findings from previous DBS studies using the classic stop-signal task. The shortened go latencies observed among PD patients fell within the control range. In contrast, stopping latencies among PD patients, although reduced significantly, continued to be significantly longer than those of the HC. Like go latencies, stop-change latencies were reduced sufficiently among PD patients for them to fall within the control range, a novel finding. In conclusion, STN DBS produced a general, but differential, improvement in the ability of PD patients to override motor actions. Going, stopping, and stop-change latencies were all shortened, but only going and stop-change latencies were normalized. |
| Databáze: | OpenAIRE |
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