The Significant Interaction of Excision Repair Cross-complementing Group 1 Genotypes and Smoking to Lung Cancer Risk
| Autor: | Da Tian Bau, Te Chun Shen, Chi-Li Gong, Li-Hsiou Chen, Chia-Wen Tsai, Yu-Chen Hsiau, Chia-Hsiang Li, Yun-Chi Wang, Wen-Shin Chang, Zhi-Hong Wang, Te Chun Hsia, Kuo-Liang Chiu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Lung Neoplasms DNA Repair Genotype Taiwan Biochemistry Polymorphism Single Nucleotide Risk Assessment Cigarette Smoking 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Genetics medicine Humans Genetic Predisposition to Disease Allele Lung cancer Molecular Biology Excision repair cross-complementing Alleles Aged business.industry Confounding Factors Epidemiologic Middle Aged medicine.disease Endonucleases Confidence interval DNA-Binding Proteins 030220 oncology & carcinogenesis Case-Control Studies Smoking status Female ERCC1 business Nucleotide excision repair Research Article |
| Zdroj: | Cancer Genomics Proteomics |
| Popis: | Background The study aims to evaluate the contribution of excision repair cross-complementing group 1 (ERCC1), which plays an important role in genome integrity maintenance, to lung cancer risk. Materials and methods ERCC1 rs11615 and rs3212986 genotypes were identified by polymerase chain reaction-restriction fragment length polymorphism analysis and their association with lung cancer risk was examined among 358 lung cancer patients and 716 controls. Results The proportions of CC, CT and TT for the rs11615 genotype were 43.6%, 41.6% and 14.8% in the case group and 50.0%, 41.1% and 8.9% in the control group, respectively (p for trend=0.0082). Allelic analysis showed that ERCC1 rs11615 T-allele carriers have a 1.32-fold higher risk of lung cancer than wild-type C-allele carriers [95%confidence interval (CI)=1.09-1.60, p=0.0039]. In addition, a significant interaction between the rs11615 genotype and smoking status was observed. Conclusion The T allele of ERCC1 rs11615 jointly with smoking habits may contribute to a higher lung cancer risk in Taiwan. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|