Biliary atresia: the Croatian experience 1992–2006
Autor: | Ruža Grizelj, Jurica Vuković, Milivoj Novak, Stipe Batinica |
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Rok vydání: | 2010 |
Předmět: |
Male
medicine.medical_specialty Pediatrics Croatia medicine.medical_treatment Portoenterostomy Hepatic Liver transplantation Biliary Atresia Biliary atresia Epidemiology medicine Humans Child Survival rate Survival analysis Retrospective Studies business.industry Incidence Incidence (epidemiology) Infant Newborn Infant Retrospective cohort study Biliary atresia . Children . Incidence . Kasai portoenterostomy medicine.disease Survival Analysis Liver Transplantation Surgery Biliary Tract Surgical Procedures Treatment Outcome Biliary tract Pediatrics Perinatology and Child Health Female business Follow-Up Studies |
Zdroj: | European Journal of Pediatrics. 169:1529-1534 |
ISSN: | 1432-1076 0340-6199 |
Popis: | The objective of this study was to determine the outcomes of Croatian children with biliary atresia. Health records of infants born in Croatia between January 1, 1992 and December 31, 2006 who were diagnosed with biliary atresia and treated at a single university center were reviewed. Survival rates were calculated with the Kaplan–Meier method. Twenty-nine patients with biliary atresia were identified. Incidence was one in 23, 600 live births (95% confidence interval 1/17, 400–1/27, 200). The median age at Kasai operation was 66 days (range 22–192). Median follow-up was 2.65 years (range 0.2–14.3). Overall survival rates for the patients who underwent Kasai portoenterostomy, including those six (20%) who subsequently underwent liver transplantation, were 75.6%. Five and 10-year native liver survival rates were 51.7% and 38.8%, respectively (median survival time was 7.88 years). Survival rate curves in two groups of patients according to the biliary atresia phenotype (fetal or perinatal form) were divergent. Survival was 87.7% in perinatal form and 43.8% in fetal form (Breslow chi-square 8.082, p |
Databáze: | OpenAIRE |
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