Longitudinal effect of amitriptyline and fluoxetine treatment on plasma phenylacetic acid concentrations in depression
| Autor: | Satish Shrikhande, S. Saleh, David L. Keegan, Rudradeo C. Bowen, Bruce A. Davis, Stella L. Blackshaw, Gabriel H. Stegeman, David A. Durden, Alan A. Boulton, N. Dayal, Alfred J. Remillard, Carl D'Arcy, I. Alick Paterson, Peter H. Yu |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Personality Tests medicine.medical_specialty Monoamine oxidase Amitriptyline Phenylacetic acid chemistry.chemical_compound Double-Blind Method Internal medicine Fluoxetine Blood plasma medicine Humans Platelet Longitudinal Studies Biological Psychiatry Depression (differential diagnoses) Aged Phenylacetates Psychiatric Status Rating Scales Depressive Disorder Mao activity biochemical phenomena metabolism and nutrition Middle Aged Endocrinology chemistry Female Psychology medicine.drug |
| Zdroj: | Biological psychiatry. 30(6) |
| ISSN: | 0006-3223 |
| Popis: | Unconjugated (U-PAA), conjugated (C-PAA), and total phenylacetic acid (T-PAA) concentrations in blood plasma and monoamine oxidase (MAO) activity in platelets towards phenylethylamine (PE) were determined in 40 drug-free, depressed patients (23 melancholic, 17 nonmelancholic) from five psychiatric treatment centers, and in 34 normal healthy volunteers. No significant differences were found between controls and all depressed patients or between melancholic and nonmelancholic depressed patients. Treatment of the depressed patients with amitriptyline or fluoxetine over a 6-week period resulted in clinical improvement and in a significant increase in plasma PAA concentrations. A decline in the Beck and Hamilton rating scores during treatment correlated significantly with increases in the concentrations of unconjugated, conjugated, and total phenylacetic acid but not with MAO activity, which did not change during treatment. At each of the three assessment times, however, plasma PAA concentrations and psychiatric rating scores were not significantly correlated. Except for higher end-of-study T-PAA concentrations in the amitriptyline-treated subjects, no significant differences were found between the effects of the two drugs with regard to plasma phenylacetic acid levels, MAO activity, or rating scores. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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