Fluconazole in the Treatment of Mycotic Oropharyngeal Stomatitis and Esophagitis in Neutropenic Cancer Patients
| Autor: | V. Savko, J. Sufliarsky, M. Blahova, Ch. Migom, Stanislav Spanik, I. Koza, Fuchsberger P, J. Mardiak, M. Horníková, Vladimir Krcmery |
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| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Neutropenia medicine.medical_treatment Administration Oral Antineoplastic Agents Anticancer chemotherapy Gastroenterology Candidiasis Oral Neoplasms Internal medicine Drug Discovery medicine Esophagitis Humans Pharmacology (medical) Fluconazole Stomatitis Mycosis Pharmacology Chemotherapy business.industry Cancer Pharyngitis General Medicine medicine.disease Infectious Diseases Mycoses Oncology Injections Intravenous Immunology Drug Evaluation Female business medicine.drug |
| Zdroj: | Chemotherapy. 37:343-345 |
| ISSN: | 1421-9794 0009-3157 |
| Popis: | The efficacy and safety of fluconazole, a new triazole antifungal agent, was evaluated in 24 patients with neutropenia due to cytotoxic anticancer chemotherapy with polyfactorial immunodepression. Twenty of 23 patients benefited from treatment, and except for 1 patient with mild abdominal discomfort the drug was well tolerated. Mycological eradication appeared in 17 from 23 evaluable patients, superinfection in 1 case and persistence could be evaluated in 5 cases. Candida albicans, C. crusei and C. pseudotropicalis together with Torulopsis sp. were the most frequently isolated organisms from pharyngeal and esophageal mucosa in treated patients with oropharyngeal and esophageal mycosis. |
| Databáze: | OpenAIRE |
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