Open loop optogenetic control of simulated cortical epileptiform activity
| Autor: | Jamie Sleigh, Andrew J. Szeri, Walter J. Freeman, Heidi E. Kirsch, Prashanth Selvaraj |
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| Rok vydání: | 2013 |
| Předmět: |
Cognitive Neuroscience
Models Neurological Population Optogenetics Meso scale Cellular and Molecular Neuroscience Seizures medicine Humans education Ion channel Cerebral Cortex Neurons Physics education.field_of_study fungi Open-loop controller Life Sciences Conductance Sensory Systems Cortex (botany) medicine.anatomical_structure Cerebral cortex Neuroscience Photic Stimulation |
| Zdroj: | Selvaraj, Prashanth; Sleigh, Jamie W.; Freeman, Walter J.; Kirsch, Heidi E.; & Szeri, Andrew J.(2014). Open loop optogenetic control of simulated cortical epileptiform activity. Journal of Computational Neuroscience. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/7zv2r9vb |
| ISSN: | 1573-6873 0929-5313 |
| DOI: | 10.1007/s10827-013-0484-2 |
| Popis: | We present a model for the use of open loop optogenetic control to inhibit epileptiform activity in a meso scale model of the human cortex. The meso scale cortical model first developed by Liley et al. (2001) is extended to two dimensions and the nature of the seizure waves is studied. We adapt to the meso scale a 4 state functional model of Channelrhodopsin-2 (ChR2) ion channels. The effects of pulsed and constant illumination on the conductance of these ion channels is presented. The inhibitory cell population is targeted for the application of open loop control. Seizure waves are successfully suppressed and the inherent properties of the optogenetic channels ensures charge balance in the cortex, protecting it from damage. |
| Databáze: | OpenAIRE |
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