Neutrophil extracellular traps in sterile inflammation: the story after dying?

Autor:	Christine Schorn, Chunyu Tan, Yi Zhao, Honghu Tang, Bei-Bei Cui, Yi Liu
Rok vydání:	2012
Předmět:	Immune defense Neutrophils Sterile inflammation medicine.medical_treatment Immunology Apoptosis Inflammation Adaptive Immunity Biology Neutrophil Activation Autoimmune Diseases Targeted therapy Mice medicine Animals Humans Immunology and Allergy Autoimmune disease Dendritic Cells Neutrophil extracellular traps Acquired immune system medicine.disease medicine.symptom
Zdroj:	Autoimmunity. 45:593-596
ISSN:	1607-842X 0891-6934
DOI:	10.3109/08916934.2012.719952
Popis:	Evidences accumulated that the death of neutrophils are not the end of their missions. The neutrophil extracellular traps (NETs), web-like structure, formed after neutrophils dying contribute greatly to immune defense, in both innate and adaptive immunity. Interestingly, previous studies revealed that the generation and activation of NETs do not only rely on bacteria induction, but also in patients with sterile inflammatory diseases, implying an undeniable correlation between NETs and these diseases. This review summarized the latest findings that the crucial roles of NETs in sterile inflammatory diseases, as well as novel targeted therapy based on these new discoveries.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43feab2b8560ef2bcda248e022c857bc https://doi.org/10.3109/08916934.2012.719952 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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