Endocuff-assisted colonoscopy for surveillance of serrated polyposis syndrome: a multicenter randomized controlled trial
| Autor: | Ariadna Sánchez, Coral Arnau-Collell, Cristina Rodríguez de Miguel, Josep Llach, Jorge López Vicente, Ignasi Puig, Mireia Díaz, Oswaldo Ortiz, Leticia Moreira, Liseth Rivero-Sánchez, Francesc Balaguer, Luis Hernandez Villalba, Sabela Carballal, Teresa Ocaña, Miriam Cuatrecasas, Lorena Moreno, Maria Pellise |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Adenoma Colorectal cancer Population Colonoscopy Withdrawal time Gastroenterology law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans education Early Detection of Cancer education.field_of_study medicine.diagnostic_test business.industry Reproducibility of Results Equipment Design Middle Aged medicine.disease Serrated polyposis Confidence interval Adenomatous Polyposis Coli 030220 oncology & carcinogenesis Colonic Neoplasms Female 030211 gastroenterology & hepatology business |
| Zdroj: | Endoscopy. 51:637-645 |
| ISSN: | 1438-8812 0013-726X |
| DOI: | 10.1055/a-0925-4956 |
| Popis: | Background and study aims Serrated polyposis syndrome (SPS) is a condition with high risk for colorectal cancer. The Endocuff device has been shown to increase adenoma detection in the general and screening population. We aimed to ascertain whether Endocuff-assisted colonoscopy increases detection of serrated lesions in comparison with standard colonoscopy during the surveillance of patients with SPS. Methods In a multicenter randomized controlled study, patients who met SPS criteria I and/or III under surveillance (previous resection of all serrated lesions ≥ 4 mm) were consecutively randomly allocated 1:1 to Endocuff-assisted colonoscopy or standard colonoscopy, performed by expert endoscopists. The main outcome was the mean number of serrated lesions detected per patient. Results 122 patients (standard colonoscopy n = 60; Endocuff-assisted colonoscopy n = 62; 59 % men; mean age 60.6 (standard deviation [SD] 7.5) were included at 4 centers. Baseline variables (demographic data, SPS phenotype, colorectal cancer [CRC] history, cumulative polyps, and follow-up), cecal intubation rate, and withdrawal time were similar between groups. There was no statistically significant difference between Endocuff-assisted colonoscopy and standard colonoscopy for the mean number of serrated lesions detected per patient: 5.8 (95 % confidence interval [95 %CI] 4.4 – 7.2) and 5.0 (3.9 – 6.1), respectively (P = 0.36). There were also no differences between Endocuff-assisted and standard colonoscopy for detection of sessile serrated lesions (mean number per patient 2.5 [1.3 – 3.6] vs. 2.0 [1.1 – 3.0], P = 0.54) and adenomas (0.9 [0.5 – 1.3] vs. 0.5 [0.3 – 0.7], P = 0.12). Conclusion Use of Endocuff-assisted colonoscopy did not significantly increase the number of serrated lesion detected per patient during surveillance of SPS. |
| Databáze: | OpenAIRE |
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